Adiabatically coupled systems and fractional monodromy

We present a 1-parameter family of systems with fractional monodromy and adiabatic separation of motion. We relate the presence of monodromy to a redistribution of states both in the quantum and semi-quantum spectrum. We show how the fractional monodromy arises from the non diagonal action of the dynamical symmetry of the system and manifests itself as a generic property of an important subclass of adiabatically coupled systems

The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo

We used the opportunities afforded by the zebrafish to determine upstream pathways regulating mast cell development in vivo and identify their cellular origin. Colocalization studies demonstrated zebrafish notch receptor expression in cells expressing carboxypeptidase A5 (cpa5), a zebrafish mast cell-specific marker. Inhibition of the Notch pathway resulted in decreased cpa5 expression in mindbomb mutants and wild-type embryos treated with the γ-secretase inhibitor, Compound E.Aseries of morpholino knockdown studies specifically identified notch1b and gata2 as the critical factors regulating mast cell fate. Moreover, hsp70::GAL4;UAS::nicd1a transgenic embryos overexpressing an activated form of notch1, nicd1a, displayed increased cpa5, gata2, and pu.1 expression. This increase in cpa5 expression could be reversed and reduced below baseline levels in a dose-dependent manner usingCompound E. Finally, evidence that cpa5 expression colocalizes with lmo2 in the absence of hematopoietic stem cells revealed that definitive mast cells initially delineate from erythromyeloid progenitors. These studies identify a master role for Notch signaling in vertebrate mast cell development and establish developmental origins of this lineage. Moreover, these findings postulate targeting the Notch pathway as a therapeutic strategy in mast cell diseases. © 2012 by The American Society of Hematology

Spontaneous DC Current Generation in a Resistively Shunted Semiconductor Superlattice Driven by a TeraHertz Field

We study a resistively shunted semiconductor superlattice subject to a high-frequency electric field. Using a balance equation approach that incorporates the influence of the electric circuit, we determine numerically a range of amplitude and frequency of the ac field for which a dc bias and current are generated spontaneously and show that this region is likely accessible to current experiments. Our simulations reveal that the Bloch frequency corresponding to the spontaneous dc bias is approximately an integer multiple of the ac field frequency.Comment: 8 pages, Revtex, 3 Postscript figure

Multiple-look effects on temporal discrimination within sound sequences

The multiple-look notion holds that the difference limen (DL) decreases with multiple observations. We investigated this notion for temporal discrimination in isochronous sound sequences. In Experiment 1, we established a multiple-look effect when sequences comprised nine standard time intervals (S) followed by an increasing number of comparison time intervals (C), but no multiple-look effect when one trailing C interval was preceded by an increasing number of S intervals. In Experiment 2, we extended the design. There were four sequential conditions: (a) 9 leading S intervals followed by 1, 2, …, or 9 C-intervals; (b) 9 leading C intervals followed by 1, 2, …, or 9 S intervals; (c) 9 trailing C-intervals preceded by 1, 2, …, or 9 S-intervals; and (d) 9 trailing S-intervals preceded by 1, 2, …, or 9 C-intervals. Both the interval accretions before and after the tempo change caused multiple-look effects, irrespective of the time order of S and C. Complete deconfounding of the number of intervals before and after the tempo change was accomplished in Experiment 3. The multiple-look effect of interval accretion before the tempo change was twice as big as that after the tempo change. The diminishing returns relation between the DL and interval accretion could be described well by a reciprocal function

JRA3 Electromagnetic Calorimeter Technical Design Report

This report describes the design of the prototype for an Silicon Tungsten electromagnetic calorimeter with unprecedented high granularity to be operated in a detector at the International Linear Collider (ILC). The R&D for the prototype is co-funded by the European Union in the FP6 framework within the so called EUDET project in the years 2006-2010. The dimensions of the prototype are similar to those envisaged for the final detector. Already at this stage the prototype features a highly compact design. The sensitive layers, the Very Front End Electronics serving 64 channels per ASIC and copper plates for heat draining are integrated within 2000 μm

Phase transition between synchronous and asynchronous updating algorithms

We update a one-dimensional chain of Ising spins of length $L$ with algorithms which are parameterized by the probability $p$ for a certain site to get updated in one time step. The result of the update event itself is determined by the energy change due to the local change in the configuration. In this way we interpolate between the Metropolis algorithm at zero temperature for $p$ of the order of 1/L and for large $L$, and a synchronous deterministic updating procedure for $p=1$. As function of $p$ we observe a phase transition between the stationary states to which the algorithm drives the system. These are non-absorbing stationary states with antiferromagnetic domains for $p>p_c$, and absorbing states with ferromagnetic domains for $p\leq p_c$. This means that above this transition the stationary states have lost any remnants to the ferromagnetic Ising interaction. A measurement of the critical exponents shows that this transition belongs to the universality class of parity conservation.Comment: 5 pages, 3 figure

A Broadband Study of the Emission from the Composite Supernova Remnant MSH 11-62

MSH 11-62 (G291.1-0.9) is a composite supernova remnant for which radio and X-ray observations have identified the remnant shell as well as its central pulsar wind nebula. The observations suggest a relatively young system expanding into a low density region. Here we present a study of MSH 11-62 using observations with the Chandra, XMM-Newton, and Fermi observatories, along with radio observations from the Australia Telescope Compact Array (ATCA). We identify a compact X-ray source that appears to be the putative pulsar that powers the nebula, and show that the X-ray spectrum of the nebula bears the signature of synchrotron losses as particles diffuse into the outer nebula. Using data from the Fermi LAT, we identify gamma-ray emission originating from MSH 11-62. With density constraints from the new X-ray measurements of the remnant, we model the evolution of the composite system in order to constrain the properties of the underlying pulsar and the origin of the gamma-ray emission.Comment: 12 Pages, 12 figures. Accepted for publication in the Astrophysical Journa

A fuzzy multi-criteria decision making approach for managing performance and risk in integrated procurement-production planning

Nowadays in Supply Chain (SC) networks, a high level of risk comes from SC partners. An effective risk management process becomes as a consequence mandatory, especially at the tactical planning level. The aim of this article is to present a risk-oriented integrated procurement–production approach for tactical planning in a multi-echelon SC network involving multiple suppliers, multiple parallel manufacturing plants, multiple subcontractors and several customers. An originality of the work is to combine an analytical model allowing to build feasible scenarios and a multi-criteria approach for assessing these scenarios. The literature has mainly addressed the problem through cost or profit-based optimisation and seldom considers more qualitative yet important criteria linked to risk, like trust in the supplier, flexibility or resilience. Unlike the traditional approaches, we present a method evaluating each possible supply scenario through performance-based and risk-based decision criteria, involving both qualitative and quantitative factors, in order to clearly separate the performance of a scenario and the risk taken if it is adopted. Since the decision-maker often cannot provide crisp values for some critical data, fuzzy sets theory is suggested in order to model vague information based on subjective expertise. Fuzzy Technique for Order of Preference by Similarity to Ideal Solution is used to determine both the performance and risk measures correlated to each possible tactical plan. The applicability and tractability of the proposed approach is shown on an illustrative example and a sensitivity analysis is performed to investigate the influence of criteria weights on the selection of the procurement–production plan